Researchers have found a new cellular pathway that could help in developing therapeutic treatments for obesity-related disorders, like diabetes and heart disease.
The medical scientists found that action by the enzyme histone deacetylase 9 (HDAC9) could be targets for potential treatment options in obesity-related diseases.
Researchers were really interested in the tie between increased HDAC9 levels in fat tissue of mice and the caloric overload. Fat tissues from these obese mice showed dysfunction, with increased expression of pro-inflammatory agents and decreased expression of hormones responsible for maintaining whole body lipid and glucose stability.
HDAC9 level in fat cells is the underlying molecular culprit for dysfunctional fat tissue during obesity.
The researchers are currently examining HDAC9 knockout mice subjected to chronic high-fat feeding and think that HDAC9 gene removal will protect mice from obesity-linked adipose tissue dysfunction and associated metabolic disorders.
The team is pursuing studies to understand how diet regulates HDAC9 levels in fat tissue and how HDAC9 up-regulation can be prevented during diet-induced obesity through pharmacological means. Their findings may help lead researchers to targeted therapies that may prevent the development of obesity-related disorders in humans reports the American Association for Long-Term Care Insurance which tracks scientific research impacting the long-term health of Americans.
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